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细胞因子与培养因子

细胞因子是介导细胞间通讯、免疫调节、造血和组织稳态的重要分泌蛋白。不同因子通过特异性受体和信号通路调控细胞活化、增殖、迁移、存活及谱系分化，是免疫学、细胞生物学和体外模型研究中的基础工具。

不同细胞因子通过特异性受体连接胞外信号与胞内响应：IFN 主要经细胞因子受体激活 JAK-STAT，CCL/CXCL 趋化因子通过 GPCR 调控迁移信号，EGF/FGF 经受体酪氨酸激酶启动 MAPK/ERK，而 TGF-β/BMP 则通过丝氨酸/苏氨酸激酶受体与 SMAD 通路发挥作用。实际研究中应结合目标细胞、受体表达和预期生物学读出选择分子。

研究方向免疫调节 · 造血 · 细胞培养核心应用增殖分化 · 模型培养 · 活性检测

产品特点与应用领域

细胞因子与培养因子产品

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应用案例与研究方向

免疫调节研究

IL-2 与 IL-6 介导的免疫细胞增殖

Dose-response curve showing IL-2-induced proliferation of CTLL-2 cells
Human IL-2 produced a concentration-dependent proliferative response in CTLL-2 cells. The reported specific activity was at least 1.20 × 10⁷ IU/mg after calibration against the applicable IL-2 reference standard.
Dose-response curve showing IL-6-induced proliferation of TF-1 cells
Human IL-6 stimulated proliferation of TF-1 erythroleukemia cells in a dose-dependent cell-based assay, with a reported specific activity above 1.00 × 10⁸ IU/mg.

细胞增殖与分化

VEGF 与 EGF 受体信号激活

VEGF165 dose-response curve in a VEGFR2 reporter cell assay
Human VEGF165 activated 293-NFAT/Luc-VEGFR2 reporter cells in a concentration-dependent manner, confirming functional engagement of the VEGFR2 signaling pathway.
EGF dose-response curve in an EGFR luciferase reporter cell assay
Human EGF triggered a dose-dependent luminescent response in EGFR reporter HEK293 cells, with a reported specific activity above 3.00 × 10⁵ IU/mg.

干细胞与模型培养

R-Spondin 1 与 FGF2 培养相关活性

R-Spondin 1 dose-response curve in a TCF reporter assay
Human R-Spondin 1 induced TCF reporter activity in HEK293 cells, with a reported EC50 range of 0.0035-0.0040 µg/mL.
FGF2 dose-response curve showing proliferation of NIH-3T3 cells
A stabilized human FGF2 variant promoted NIH-3T3 cell proliferation in a concentration-dependent assay, with a reported specific activity above 1.60 × 10⁷ IU/mg.

活性与功能检测

VEGF165 功能响应与抑制实验

Inhibition curve for anti-VEGF antibody in a VEGF165 proliferation assay
An anti-VEGF monoclonal antibody reduced the VEGF165-driven proliferative response as its concentration increased; the reported ED50 range was 0.065-0.229 µg/mL.
VEGF165 dose-response curve showing reporter induction fold
Serially diluted human VEGF165 generated a concentration-dependent response in a VEGFR2 luciferase reporter assay, reaching approximately 70-fold maximum induction.

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