Human MRGPRX2 Nanodisc Protein

Name: Human MRGPRX2 Nanodisc Protein
Brand: 普维拓生物
SKU: MRGPRX2-HP002

货号MRGPRX2-HP002

HumanHEK293分子名 · MRGX2

产品简介

Human MRGPRX2 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human MRGPRX2 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val330 (accession: Q96LB1).

产品详情

分子别名: MRGX2
蛋白长度: Met1-Val330
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.

文献引用

1.Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.

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