Human MRGPRX2 Nanodisc Protein

Name: Human MRGPRX2 Nanodisc Protein
Brand: Puweituo Bio
SKU: MRGPRX2-HP002

Catalog numberMRGPRX2-HP002

HumanHEK293Molecule · MRGX2

Product introduction

Human MRGPRX2 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human MRGPRX2 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val330 (accession: Q96LB1).

Product details

Molecular aliases: MRGX2
Protein length: Met1-Val330
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.

References

1.Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.

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