Human MRGPRX2 VLP Protein

Name: Human MRGPRX2 VLP Protein
Brand: 普维拓生物
SKU: MRGPRX2-HP001

货号MRGPRX2-HP001

HumanHEK293分子名 · MRGX2理论分子量 · 40.31 kDa

产品简介

Human MRGPRX2 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human MRGPRX2 VLP is expressed from HEK293. It contains Met1-Val330 (It may have cross reaction with anti-His antibody) (accession: Q96LB1).

产品详情

分子别名: MRGX2
蛋白长度: Met1-Val330
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 40.31 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.

文献引用

1.Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.

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