Human MRGPRX2 VLP Protein

Name: Human MRGPRX2 VLP Protein
Brand: Puweituo Bio
SKU: MRGPRX2-HP001

Catalog numberMRGPRX2-HP001

HumanHEK293Molecule · MRGX2Molecular weight · 40.31 kDa

Product introduction

Human MRGPRX2 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human MRGPRX2 VLP is expressed from HEK293. It contains Met1-Val330 (It may have cross reaction with anti-His antibody) (accession: Q96LB1).

Product details

Molecular aliases: MRGX2
Protein length: Met1-Val330
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 40.31 kDa.
Purity: > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.

References

1.Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.

加载中…