Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

Name: Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)
Brand: 普维拓生物
SKU: CTLA4-AB001

货号CTLA4-AB001

HumanHEK293理论分子量 · 51.4 kDa

产品简介

Anti-CTLA-4 Antibody (Ipilimumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CTLA-4, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

产品详情

表达系统: HEK293
理论分子量: 51.4 kDa and 23 kDa.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: PBS, 10% glycerol (pH 7.4)
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Ipilimumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Ipilimumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CTLA-4, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Ipilimumab Biosimilar with the EC50 of 12.1ng/ml determined by ELISA. (QC Test)

背景介绍

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

文献引用

1.Merwe V D, P. A. CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics[J]. Journal of Experimental Medicine, 1997, 185(3):393-404.

Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用