Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

Name: Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)
Brand: Puweituo Bio
SKU: CTLA4-AB001

Catalog numberCTLA4-AB001

HumanHEK293Molecular weight · 51.4 kDa

Product introduction

Anti-CTLA-4 Antibody (Ipilimumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CTLA-4, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 51.4 kDa and 23 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Ipilimumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Ipilimumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CTLA-4, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Ipilimumab Biosimilar with the EC50 of 12.1ng/ml determined by ELISA. (QC Test)

Background

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

References

1.Merwe V D, P. A. CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics[J]. Journal of Experimental Medicine, 1997, 185(3):393-404.

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Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

Catalog numberCTLA4-AB001

HumanHEK293Molecular weight · 51.4 kDa

Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-CTLA-4 Antibody (Ipilimumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References