Biotinylated Human Claudin 18.2 Nanodisc

Name: Biotinylated Human Claudin 18.2 Nanodisc
Brand: 普维拓生物
SKU: CLDN182-HB004

货号CLDN182-HB004

HumanHEK293分子名 · CLDN18理论分子量 · 40.60 kDa

产品简介

Recombinant Biotinylated Human Claudin 18.2 Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Val261 (UniProt accession: P56856-2).

产品详情

分子别名: CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ
蛋白长度: Met1-Val261
表达系统: HEK293
理论分子量: The protein has a predicted MW of 40.60 kDa.
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: CON-HM1NB

数据展示

ELISA Data — Immobilized Biotinylated Human Claudin 18.2 Nanodisc, His Tag at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Claudin18.2 Antibody, hFc Tag with the EC50 of 52.2ng/ml determined by ELISA. (QC Test)

SPR Data — Biotinylated Human Claudin 18.2 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 5.72 nM as determined in SPR assay (Biacore T200).

背景介绍

Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

文献引用

1.Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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Biotinylated Human Claudin 18.2 Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human Claudin 18.2 Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用