Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

Name: Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)
Brand: 普维拓生物
SKU: CLDN182-AB001

货号CLDN182-AB001

HumanHEK293理论分子量 · 49.4 kDa

产品简介

Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Claudin 18.2, reactivity Human, isotype Human IgG1-Kappa, source-listed application ELISA.

产品详情

表达系统: HEK293
理论分子量: 49.4 kDa and 24.2 kDa.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: PBS, 10% glycerol (pH 7.4)
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Zolbetuximab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Zolbetuximab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Claudin18.2 VLP at 5μg/ml (100μl/well) on the plate. Dose response curve for Zolbetuximab Biosimilar with the EC50 of 7.8ng/ml determined by ELISA. (QC Test)

背景介绍

Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

文献引用

1.Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用