Biotinylated Human Claudin 18.2 VLP

Name: Biotinylated Human Claudin 18.2 VLP
Brand: 普维拓生物
SKU: CLDN182-HB003

货号CLDN182-HB003

HumanHEK293分子名 · CLDN18理论分子量 · 29 kDa

产品简介

Recombinant Biotinylated Full length Human Claudin 18.2 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Val261 (It may have cross reaction with anti-His antibody) (UniProt accession: P56856-2).

产品详情

分子别名: CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ
蛋白长度: Met1-Val261
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 29 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: GPR-HM05CB

数据展示

SEC-HPLC Data — The purity of Biotinylated Human Claudin 18.2 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human Claudin18.2 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-Claudin18.2 Antibody, hFc Tag with the EC50 of 16.1ng/ml determined by ELISA (QC Test).

SPR Data — Biotinylated Human Claudin18.2 VLP captured on CM5 Chip via Streptavidin can bind Anti-Claudin18.2 Antibody with an affinity constant of 1.28 nM as determined in SPR assay (Biacore T200).

背景介绍

Claudin18(CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants,CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

文献引用

1.Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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Biotinylated Human Claudin 18.2 VLP

货号CLDN182-HB003

HumanHEK293分子名 · CLDN18理论分子量 · 29 kDa

Biotinylated Human Claudin 18.2 VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human Claudin 18.2 VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用