Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

Name: Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)
Brand: Puweituo Bio
SKU: CLDN182-AB001

Catalog numberCLDN182-AB001

HumanHEK293Molecular weight · 49.4 kDa

Product introduction

Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Claudin 18.2, reactivity Human, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.4 kDa and 24.2 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Zolbetuximab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Zolbetuximab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Claudin18.2 VLP at 5μg/ml (100μl/well) on the plate. Dose response curve for Zolbetuximab Biosimilar with the EC50 of 7.8ng/ml determined by ELISA. (QC Test)

Background

Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

References

1.Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-Claudin 18.2 Antibody (Zolbetuximab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References