Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

Name: Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)
Brand: 普维拓生物
SKU: ACTIVINRIIB-AB001

货号ACTIVINRIIB-AB001

HumanHEK293理论分子量 · 50.8 kDa

产品简介

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Activin RIIB, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

产品详情

表达系统: HEK293
理论分子量: 50.8 kDa and 22.73 kDa.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: PBS, 10% glycerol (pH 7.4)
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Bimagrumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Bimagrumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Activin RIIB, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Bimagrumab Biosimilar with the EC50 of 4.3ng/ml determined by ELISA. (QC Test)

背景介绍

ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).

文献引用

1.Sakamoto K, Kanematsu-Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, Asami T, Inooka H. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017 Jun 10;11:33-39. doi: 10.1016/j.bbrep.2017.06.001. PMID: 28955765; PMCID: PMC5614685.

加载中…

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

货号ACTIVINRIIB-AB001

HumanHEK293理论分子量 · 50.8 kDa

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用