Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

Name: Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)
Brand: Puweituo Bio
SKU: ACTIVINRIIB-AB001

Catalog numberACTIVINRIIB-AB001

HumanHEK293Molecular weight · 50.8 kDa

Product introduction

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target Activin RIIB, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 50.8 kDa and 22.73 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Bimagrumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Bimagrumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human Activin RIIB, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Bimagrumab Biosimilar with the EC50 of 4.3ng/ml determined by ELISA. (QC Test)

Background

ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).

References

1.Sakamoto K, Kanematsu-Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, Asami T, Inooka H. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017 Jun 10;11:33-39. doi: 10.1016/j.bbrep.2017.06.001. PMID: 28955765; PMCID: PMC5614685.

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Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

Catalog numberACTIVINRIIB-AB001

HumanHEK293Molecular weight · 50.8 kDa

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-Activin RIIB Antibody (Bimagrumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References