Biotinylated Human SLC2A4 VLP

Name: Biotinylated Human SLC2A4 VLP
Brand: 普维拓生物
SKU: SLC2A4-HB001

货号SLC2A4-HB001

HumanHEK293分子名 · GLUT-4; GLUT4理论分子量 · 67.46 kDa

产品简介

Recombinant Biotinylated Human SLC2A4 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Asp509 (It may have cross reaction with anti-His antibody) (UniProt accession: P14672-1).

产品详情

分子别名: GLUT-4; GLUT4
蛋白长度: Met1-Asp509
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 67.46 kDa.
纯度: > 95% as determined by HPLC
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: CON-HM00VB

数据展示

SEC-HPLC Data — The purity of Biotinylated Human SLC2A4 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human SLC2A4 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-SLC2A4 Antibody, hFc Tag with the EC50 of 40.9ng/ml determined by ELISA. (QC Test)

SPR Data — Biotinylated Human SLC2A4 VLP captured on CM5 Chip via Streptavidin can bind Anti-SLC2A4 Antibody, hFc Tag with an affinity constant of 0.55 nM as determined in SPR assay (Biacore S200).

背景介绍

SLC2A4 (GLUT4) is an insulin-responsive glucose transporter mainly expressed in muscle and adipose tissues. Its unique feature is insulin-regulated translocation to the plasma membrane, which determines cellular glucose uptake. Defects in this process are a key molecular basis of insulin resistance and type 2 diabetes.

文献引用

1.Drobiova H, Alhamar G, Ahmad R, Al-Mulla F, Al Madhoun A. GLUT4 Trafficking and Storage Vesicles: Molecular Architecture, Regulatory Networks, and Their Disruption in Insulin Resistance. Int J Mol Sci. 2025 Aug 5;26(15):7568. doi: 10.3390/ijms26157568. PMID: 40806697; PMCID: PMC12347429.
2.Jin Y, Cheng X, Wu J, Zhu Y, Xu H, Cao C. Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway in vitro. Exp Ther Med. 2025 Aug 22;30(5):206. doi: 10.3892/etm.2025.12956. PMID: 40927642; PMCID: PMC12415508.

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Biotinylated Human SLC2A4 VLP

货号SLC2A4-HB001

HumanHEK293分子名 · GLUT-4; GLUT4理论分子量 · 67.46 kDa

产品简介

Recombinant Biotinylated Human SLC2A4 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Asp509 (It may have cross reaction with anti-His antibody) (UniProt accession: P14672-1).

Biotinylated Human SLC2A4 VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human SLC2A4 VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用