Biotinylated Human SLC2A4 VLP

Name: Biotinylated Human SLC2A4 VLP
Brand: Puweituo Bio
SKU: SLC2A4-HB001

Catalog numberSLC2A4-HB001

HumanHEK293Molecule · GLUT-4; GLUT4Molecular weight · 67.46 kDa

Product introduction

Recombinant Biotinylated Human SLC2A4 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Asp509 (It may have cross reaction with anti-His antibody) (UniProt accession: P14672-1).

Product details

Molecular aliases: GLUT-4; GLUT4
Protein length: Met1-Asp509
Expression system: HEK293
Molecular weight: The target protein has a predicted MW of 67.46 kDa.
Purity: > 95% as determined by HPLC
Formulation: Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Negative control: CON-HM00VB

Data display

SEC-HPLC Data — The purity of Biotinylated Human SLC2A4 VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human SLC2A4 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-SLC2A4 Antibody, hFc Tag with the EC50 of 40.9ng/ml determined by ELISA. (QC Test)

SPR Data — Biotinylated Human SLC2A4 VLP captured on CM5 Chip via Streptavidin can bind Anti-SLC2A4 Antibody, hFc Tag with an affinity constant of 0.55 nM as determined in SPR assay (Biacore S200).

Background

SLC2A4 (GLUT4) is an insulin-responsive glucose transporter mainly expressed in muscle and adipose tissues. Its unique feature is insulin-regulated translocation to the plasma membrane, which determines cellular glucose uptake. Defects in this process are a key molecular basis of insulin resistance and type 2 diabetes.

References

1.Drobiova H, Alhamar G, Ahmad R, Al-Mulla F, Al Madhoun A. GLUT4 Trafficking and Storage Vesicles: Molecular Architecture, Regulatory Networks, and Their Disruption in Insulin Resistance. Int J Mol Sci. 2025 Aug 5;26(15):7568. doi: 10.3390/ijms26157568. PMID: 40806697; PMCID: PMC12347429.
2.Jin Y, Cheng X, Wu J, Zhu Y, Xu H, Cao C. Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway in vitro. Exp Ther Med. 2025 Aug 22;30(5):206. doi: 10.3892/etm.2025.12956. PMID: 40927642; PMCID: PMC12415508.

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Biotinylated Human SLC2A4 VLP

Catalog numberSLC2A4-HB001

HumanHEK293Molecule · GLUT-4; GLUT4Molecular weight · 67.46 kDa

Product introduction

Recombinant Biotinylated Human SLC2A4 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Asp509 (It may have cross reaction with anti-His antibody) (UniProt accession: P14672-1).

Biotinylated Human SLC2A4 VLP

Product introduction

Product details

Data display

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

Background

References

Biotinylated Human SLC2A4 VLP

Product introduction

Product details

Data display

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

Background

References