Biotinylated Human Semaphorin 4A/SEMA4A Protein

Name: Biotinylated Human Semaphorin 4A/SEMA4A Protein
Brand: 普维拓生物
SKU: SEMA4A-HB001

货号SEMA4A-HB001

HumanHEK293分子名 · Semaphorin-4A理论分子量 · 75.31 kDa

产品简介

Recombinant Biotinylated Human Semaphorin 4A/SEMA4A Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Gly33-His683 (UniProt accession: Q9H3S1-1).

产品详情

分子别名: Semaphorin-4A; Semaphorin-B; SEMA4A
蛋白长度: Gly33-His683
表达系统: HEK293
理论分子量: The protein has a predicted MW of 75.31 kDa. Due to glycosylation, the protein migrates to 85-95 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 0.1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Biotinylated Human Semaphorin 4A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Biotinylated Human Semaphorin 4A is greater than 95% as determined by SEC-HPLC.

SPR Data — Human LILRB2, hFc Tag (Cat. LIL-HM2B2) captured on CM5 Chip via Protein A can bind Biotinylated Human Semaphorin 4A, His Tag with an affinity constant of 34.05 nM as determined in SPR assay (Biacore T200).

背景介绍

Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response.

文献引用

1.Iyer AS, Chapoval SP. Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor? Int J Mol Sci. 2018 Dec 30;20(1):124. doi: 10.3390/ijms20010124. PMID: 30598022; PMCID: PMC6337608.

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Biotinylated Human Semaphorin 4A/SEMA4A Protein

货号SEMA4A-HB001

HumanHEK293分子名 · Semaphorin-4A理论分子量 · 75.31 kDa

Biotinylated Human Semaphorin 4A/SEMA4A Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human Semaphorin 4A/SEMA4A Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

SPR

SPR Data

背景介绍

文献引用