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Recombinant Biotinylated Human/Mouse/Rat Activin A Protein is expressed in HEK293 cells with an Avi tag at the C-terminus. It contains amino acid residues Gly311-Ser426 (UniProt accession: P08476).
Activin-A, a member of the TGF-β superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression.
