Biotinylated Human GPRC5D Nanodisc

Name: Biotinylated Human GPRC5D Nanodisc
Brand: 普维拓生物
SKU: GPRC5D-HB004

货号GPRC5D-HB004

HumanHEK293分子名 · GPRC5D理论分子量 · 51.70 kDa

产品简介

Recombinant Biotinylated Human GPRC5D Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Val345 (UniProt accession: Q9NZD1-1).

产品详情

分子别名: GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
蛋白长度: Met1-Val345
表达系统: HEK293
理论分子量: The protein has a predicted MW of 51.70 kDa.
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: CON-HM1NB

数据展示

ELISA Data — Immobilized Biotinylated Human GPRC5D Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate(5μg/ml). Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA (QC Test).

BLI Data — Loaded Biotinylated Human GPRC5D Nanodisc, His Tag on Streptavidin-Biosensor can bind Anti-GPRC5D Antibody, hFc Tag with an affinity constant of 2.21 nM as determined in BLI assay.

背景介绍

G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.

文献引用

1.Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.

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Biotinylated Human GPRC5D Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

BLI

BLI Data

背景介绍

文献引用

Biotinylated Human GPRC5D Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

BLI

BLI Data

背景介绍

文献引用