Cynomolgus GPRC5D VLP Protein

Name: Cynomolgus GPRC5D VLP Protein
Brand: 普维拓生物
SKU: GPRC5D-CP001

货号GPRC5D-CP001

HEK293分子名 · GPRC5D理论分子量 · 35.10 kDa

产品简介

Cynomolgus GPRC5D VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Cynomolgus GPRC5D VLP is expressed from HEK293. It contains Met1-Cys300 (It may have cross reaction with anti-His antibody) (accession: A0A2K5W6I7).

产品详情

分子别名: GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
蛋白长度: Met1-Cys300
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 35.10 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.

文献引用

1.Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.

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