Biotinylated Human GPRC5D VLP

Name: Biotinylated Human GPRC5D VLP
Brand: 普维拓生物
SKU: GPRC5D-HB003

货号GPRC5D-HB003

HumanHEK293分子名 · GPRC5D理论分子量 · 39.6 kDa

产品简介

Recombinant Biotinylated Human GPRC5D VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Val345 (It may have cross reaction with anti-His antibody) (UniProt accession: Q9NZD1-1).

产品详情

分子别名: GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
蛋白长度: Met1-Val345
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 39.6 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: GPR-HM05CB

数据展示

SEC-HPLC Data — The purity of Biotinylated Human GPRC5D VLP is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Biotinylated Human GPRC5D VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA (QC Test).

SPR Data — Biotinylated Human GPRC5D VLP captured on CM5 Chip via Streptavidin can bind Anti-GPRC5D Antibody with an affinity constant of 0.28 nM as determined in SPR assay (Biacore T200).

背景介绍

G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.

文献引用

1.Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.

加载中…

Biotinylated Human GPRC5D VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human GPRC5D VLP

产品简介

产品详情

数据展示

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用