Biotinylated Human CX3CR1 Nanodisc Protein

Name: Biotinylated Human CX3CR1 Nanodisc Protein
Brand: 普维拓生物
SKU: CX3CR1-HB001

货号CX3CR1-HB001

HumanHEK293分子名 · CX3C chemokine receptor 1

产品简介

Biotinylated Human CX3CR1 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CX3CR1 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Leu355 (accession: P49238-1).

产品详情

分子别名: CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; V28; CMKBRL1; GPR13; GPRV28
蛋白长度: Met1-Leu355
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

CX3CR1, also known as G-protein coupled receptor 13, is a receptor of CX3CL1. It is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induces the activation of heterotrimeric G proteins associated with this receptor. In addition, it triggers the signal pathways of MAPK and AKT, which play essential roles in tumour biology.

文献引用

1.Lu X. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. Curr Med Chem. 2022;29(41):6228-6246. doi: 10.2174/0929867329666220629140540. PMID: 35770395.

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