Biotinylated Human CX3CR1 Nanodisc Protein

Name: Biotinylated Human CX3CR1 Nanodisc Protein
Brand: Puweituo Bio
SKU: CX3CR1-HB001

Catalog numberCX3CR1-HB001

HumanHEK293Molecule · CX3C chemokine receptor 1

Product introduction

Biotinylated Human CX3CR1 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CX3CR1 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Leu355 (accession: P49238-1).

Product details

Molecular aliases: CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; V28; CMKBRL1; GPR13; GPRV28
Protein length: Met1-Leu355
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

CX3CR1, also known as G-protein coupled receptor 13, is a receptor of CX3CL1. It is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induces the activation of heterotrimeric G proteins associated with this receptor. In addition, it triggers the signal pathways of MAPK and AKT, which play essential roles in tumour biology.

References

1.Lu X. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. Curr Med Chem. 2022;29(41):6228-6246. doi: 10.2174/0929867329666220629140540. PMID: 35770395.

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