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Recombinant FITC-Labeled Human CD47 Protein is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Gln19-Pro139 (UniProt accession: Q08722-1).
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers.
