Biotinylated Human CCR6 Nanodisc Protein

Name: Biotinylated Human CCR6 Nanodisc Protein
Brand: 普维拓生物
SKU: CCR6-HB001

货号CCR6-HB001

HumanHEK293分子名 · C-C CKR-6

产品简介

Biotinylated Human CCR6 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Met374 (accession: P51684).

产品详情

分子别名: C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3 / CMKBR6; GPR29; STRL22; BN-1
蛋白长度: Met1-Met374
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.

文献引用

1.Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL. CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. PMID: 21376174; PMCID: PMC3063449.

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