Biotinylated Human CCR6 Nanodisc Protein

Name: Biotinylated Human CCR6 Nanodisc Protein
Brand: Puweituo Bio
SKU: CCR6-HB001

Catalog numberCCR6-HB001

HumanHEK293Molecule · C-C CKR-6

Product introduction

Biotinylated Human CCR6 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Met374 (accession: P51684).

Product details

Molecular aliases: C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3 / CMKBR6; GPR29; STRL22; BN-1
Protein length: Met1-Met374
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.

References

1.Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL. CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. PMID: 21376174; PMCID: PMC3063449.

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