Human CCR4 Nanodisc Protein

Name: Human CCR4 Nanodisc Protein
Brand: 普维拓生物
SKU: CCR4-HP001

货号CCR4-HP001

HumanHEK293分子名 · C-C CKR-4

产品简介

Human CCR4 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human CCR4 Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part). It contains Met1-Leu360 (accession: P51679).

产品详情

分子别名: C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CMKBR4; CKR-4
蛋白长度: Met1-Leu360
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS (pH 7.4) / PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

CC chemokine receptor 4 (CCR4) is a chemokine receptor mainly expressed by T cells. CCR4 is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases.

文献引用

1.(1) Yoshie O. CCR4 as a Therapeutic Target for Cancer Immunotherapy. Cancers (Basel). 2021 Nov 4;13(21):5542. doi: 10.3390/cancers13215542. PMID: 34771703; PMCID: PMC8583476.(2) Bogacka J, Pawlik K, Ciapała K, Ciechanowska A, Mika J. CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy. Int J Mol Sci. 2022 Dec 9;23(24):15638. doi: 10.3390/ijms232415638. PMID: 36555280; PMCID: PMC9779674.

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