Biotinylated Human CCR4 Nanodisc

Name: Biotinylated Human CCR4 Nanodisc
Brand: 普维拓生物
SKU: CCR4-HB001

货号CCR4-HB001

HumanHEK293分子名 · C-C CKR-4理论分子量 · 54.3 kDa

产品简介

Recombinant Biotinylated Human CCR4 Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Leu360 (UniProt accession: P51679).

产品详情

分子别名: C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CMKBR4; CKR-4; C-C CKR4; CC-CKR4; CKR4
蛋白长度: Met1-Leu360
表达系统: HEK293
理论分子量: The protein has a predicted MW of 54.3 kDa.
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
阴性对照: CON-HM1NB

数据展示

ELISA Data — Immobilized Biotinylated Human CCR4 Nanodisc, His Tag at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-CCR4 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. (QC Test)

SPR Data — Biotinylated Human CCR4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CCR4 Antibody, hFc Tag with an affinity constant of 0.64 nM as determined in SPR assay (Biacore T200).

背景介绍

CC chemokine receptor 4 (CCR4) is a chemokine receptor mainly expressed by T cells. CCR4 is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases.

文献引用

1.Yoshie O. CCR4 as a Therapeutic Target for Cancer Immunotherapy. Cancers (Basel). 2021 Nov 4;13(21):5542. doi: 10.3390/cancers13215542. PMID: 34771703; PMCID: PMC8583476.
2.Bogacka J, Pawlik K, Ciapała K, Ciechanowska A, Mika J. CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy. Int J Mol Sci. 2022 Dec 9;23(24):15638. doi: 10.3390/ijms232415638. PMID: 36555280; PMCID: PMC9779674.

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Biotinylated Human CCR4 Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用

Biotinylated Human CCR4 Nanodisc

产品简介

产品详情

数据展示

ELISA

ELISA Data

SPR

SPR Data

背景介绍

文献引用