Human CCR4 Nanodisc Protein

Name: Human CCR4 Nanodisc Protein
Brand: Puweituo Bio
SKU: CCR4-HP001

Catalog numberCCR4-HP001

HumanHEK293Molecule · C-C CKR-4

Product introduction

Human CCR4 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human CCR4 Nanodisc is expressed from HEK293 with His tag at the C-terminus (FITC-equivalent protein is fused on cytoplasmic part). It contains Met1-Leu360 (accession: P51679).

Product details

Molecular aliases: C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CMKBR4; CKR-4
Protein length: Met1-Leu360
Expression system: HEK293
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4) / PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Storage: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

Background

CC chemokine receptor 4 (CCR4) is a chemokine receptor mainly expressed by T cells. CCR4 is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases.

References

1.(1) Yoshie O. CCR4 as a Therapeutic Target for Cancer Immunotherapy. Cancers (Basel). 2021 Nov 4;13(21):5542. doi: 10.3390/cancers13215542. PMID: 34771703; PMCID: PMC8583476.(2) Bogacka J, Pawlik K, Ciapała K, Ciechanowska A, Mika J. CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy. Int J Mol Sci. 2022 Dec 9;23(24):15638. doi: 10.3390/ijms232415638. PMID: 36555280; PMCID: PMC9779674.

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