Human ACVR1B/Activin RIB Protein

Name: Human ACVR1B/Activin RIB Protein
Brand: 普维拓生物
SKU: ACVR1B-HF001

货号ACVR1B-HF001

HumanHEK293分子名 · ACVR1B理论分子量 · 37.36 kDa

产品简介

Recombinant Human ACVR1B/Activin RIB Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Ser24-Glu126 (UniProt accession: P36896-1).

产品详情

分子别名: ACVR1B; ACTR-IB; ALK 4; ALK-4; SKR2; ACVRLK4; ALK4; Activin R1B
蛋白长度: Ser24-Glu126
表达系统: HEK293
理论分子量: The protein has a predicted MW of 37.36 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
状态: 冻干粉
储存条件: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
复溶建议: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

数据展示

Bis-Tris PAGE Data — Human ACVR1B on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human ACVR1B is greater than 95% as determined by SEC-HPLC.

SPR Data — Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).

BLI Data — Loaded Human ACVR1B, hFc Tag on ProA-Biosensor can bind Human TDGF1, His Tag with an affinity constant of 0.13 µM as determined in BLI assay. (QC Test)

背景介绍

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system.

文献引用

1.Valer JA, Sánchez-de-Diego C, Pimenta-Lopes C, Rosa JL, Ventura F. ACVR1 Function in Health and Disease. Cells. 2019 Oct 31;8(11):1366. doi: 10.3390/cells8111366. PMID: 31683698; PMCID: PMC6912516.

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Human ACVR1B/Activin RIB Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

SPR

SPR Data

SPR

SPR Data

BLI

BLI Data

背景介绍

文献引用

Human ACVR1B/Activin RIB Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

SPR

SPR Data

SPR

SPR Data

BLI

BLI Data

背景介绍

文献引用