Biotinylated Cynomolgus SOST/Sclerostin Protein

Name: Biotinylated Cynomolgus SOST/Sclerostin Protein
Brand: 普维拓生物
SKU: SOST-CB001

货号SOST-CB001

HEK293分子名 · sclerostin理论分子量 · 24.39 kDa

产品简介

Recombinant Biotinylated Cynomolgus SOST/Sclerostin Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Gln69-Tyr258 (accession: XP_005584428.2).

产品详情

分子别名: sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH
蛋白长度: Gln69-Tyr258
表达系统: HEK293
理论分子量: The protein has a predicted MW of 24.39 kDa. Due to glycosylation, the protein migrates to 32-38 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Biotinylated Cynomolgus SOST on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ELISA Data — Immobilized Biotinylated Cynomolgus SOST, His Avi tag at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 37.6ng/ml determined by ELISA. (QC Test)

背景介绍

SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

文献引用

1.Claire M N, Patton D, Hayes J S. Sclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and Challenges[J]. Journal of Osteoporosis, 2016, 2016:1-22.

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Biotinylated Cynomolgus SOST/Sclerostin Protein

货号SOST-CB001

HEK293分子名 · sclerostin理论分子量 · 24.39 kDa

Biotinylated Cynomolgus SOST/Sclerostin Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

ELISA

ELISA Data

ELISA

ELISA Data

背景介绍

文献引用

Biotinylated Cynomolgus SOST/Sclerostin Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

ELISA

ELISA Data

ELISA

ELISA Data

背景介绍

文献引用