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Recombinant Biotinylated Human SLC15A4 Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Ala577 (UniProt accession: Q8N697).
SLC15A4 is a member of the SLC15 family of solute carriers, which is an endolysosome-resident amino acid transporter in immune cells that mediates the transport of L-histidine, small peptides, and NOD1/NOD2 ligands. SLC15A4 plays a critical role in TLR7/8/9-induced immune responses through assembling a complex with the downstream adaptor TASL in a conformation-dependent manner. SLC15A4 represents a promising therapeutic target for the treatment of infections, tumors, and autoimmune diseases.
