Anti-OSMR Antibody (Vixarelimab Biosimilar)

Name: Anti-OSMR Antibody (Vixarelimab Biosimilar)
Brand: 普维拓生物
SKU: OSMR-AB001

货号OSMR-AB001

HumanHEK293理论分子量 · 52 kDa

产品简介

Anti-OSMR Antibody (Vixarelimab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target OSMR, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

产品详情

表达系统: HEK293
理论分子量: 52 kDa and 22.7 kDa.
纯度: > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: PBS, 10% glycerol (pH 7.4)
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Vixarelimab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Vixarelimab Biosimilar is greater than 90% as determined by SEC-HPLC.

ELISA Data — Immobilized Human OSMR, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Vixarelimab Biosimilar with the EC50 of 3.9ng/ml determined by ELISA. (QC Test)

背景介绍

OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.

文献引用

1.Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A. OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation. Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z. PMID: 32807793; PMCID: PMC7431428.

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Anti-OSMR Antibody (Vixarelimab Biosimilar)

货号OSMR-AB001

HumanHEK293理论分子量 · 52 kDa

Anti-OSMR Antibody (Vixarelimab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Anti-OSMR Antibody (Vixarelimab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用