Anti-OSMR Antibody (Vixarelimab Biosimilar)

Name: Anti-OSMR Antibody (Vixarelimab Biosimilar)
Brand: Puweituo Bio
SKU: OSMR-AB001

Catalog numberOSMR-AB001

HumanHEK293Molecular weight · 52 kDa

Product introduction

Anti-OSMR Antibody (Vixarelimab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target OSMR, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 52 kDa and 22.7 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Vixarelimab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Vixarelimab Biosimilar is greater than 90% as determined by SEC-HPLC.

ELISA Data — Immobilized Human OSMR, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Vixarelimab Biosimilar with the EC50 of 3.9ng/ml determined by ELISA. (QC Test)

Background

OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.

References

1.Sharanek A, Burban A, Laaper M, Heckel E, Joyal JS, Soleimani VD, Jahani-Asl A. OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation. Nat Commun. 2020 Aug 17;11(1):4116. doi: 10.1038/s41467-020-17885-z. PMID: 32807793; PMCID: PMC7431428.

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Anti-OSMR Antibody (Vixarelimab Biosimilar)

Catalog numberOSMR-AB001

HumanHEK293Molecular weight · 52 kDa

Anti-OSMR Antibody (Vixarelimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-OSMR Antibody (Vixarelimab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References