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Recombinant Biotinylated Human LAP (TGF beta 1) Protein is expressed in HEK293 cells with a His tag and Avi tag at the N-terminus. It contains amino acid residues Leu30-Arg278(C33S) (UniProt accession: P01137).
Latent TGF beta 1 cDNA encodes a 390 amino acid precursor that contains a 29 aa signal peptide and a 361 aa proprotein. A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1. Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex.
