PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein

Name: PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein
Brand: 普维拓生物
SKU: KRASG12V-HP015

货号KRASG12V-HP015

HumanE. coli分子名 · MHC

产品简介

Recombinant PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. PE-Labeled Human HLA-A*11:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVGAVGVGK peptide (accession: AAV53343.1(HLA-A*11:01) & P61769(B2M) &VVGAVGVGK).

产品详情

分子别名: MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
蛋白长度: Gly25-Thr305
表达系统: E. coli
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in 20mM Tris, 200mM NaCl, 0.2% BSA (pH 8.0).
储存条件: Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

背景介绍

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

文献引用

1.(1) Wu HZ, Xiao JQ, Xiao SS, Cheng Y. KRAS: A Promising Therapeutic Target for Cancer Treatment. Curr Top Med Chem. 2019;19(23):2081-2097. doi: 10.2174/1568026619666190905164144. PMID: 31486755.

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