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Recombinant Human IL-2 R beta&IL-2 R gamma Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus of IL-2 R beta and IL-2 R gamma. It contains amino acid residues Ala27-Thr240 (IL-2 R beta) and Leu23-Ala262 (IL-2 R gamma) (accession: P14784(IL-2 R beta) & P31785-1(IL-2 R gamma)).
Wilms' tumor 1 (WT1) is a transcription factor which plays a major role in cell proliferation, differentiation, survival, and apoptosis. WT1 was first identified as a tumor suppressor gene in Wilms' tumor. The expression of survival signaling genes, IL-2, IL-2RB, and IL-2RG, was also suppressed after WT1-siRNA treatment. In addition, the WT1 silencing also inhibited the S phase of the cell cycle and induced cell death.Moreover, transcriptional modulation of IL-2, IL-2RB, and IL2-2RG expression by WT1 was likely involved in this phenotypic change.
