Anti-IGF1R Antibody (Teprotumumab Biosimilar)

Name: Anti-IGF1R Antibody (Teprotumumab Biosimilar)
Brand: 普维拓生物
SKU: IGF1R-AB001

货号IGF1R-AB001

HumanHEK293理论分子量 · 49.3 kDa

产品简介

Anti-IGF1R Antibody (Teprotumumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target IGF1R, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

产品详情

表达系统: HEK293
理论分子量: 49.3 kDa and 23.5 kDa.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: PBS, 10% glycerol (pH 7.4)
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Teprotumumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Teprotumumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human IGF1R, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Teprotumumab Biosimilar with the EC50 of 4.3ng/ml determined by ELISA. (QC Test)

背景介绍

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

文献引用

1.Riedemann J, Macaulay VM. IGF1R signalling and its inhibition. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S33-43. doi: 10.1677/erc.1.01280. PMID: 17259557.

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Anti-IGF1R Antibody (Teprotumumab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用

Anti-IGF1R Antibody (Teprotumumab Biosimilar)

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

背景介绍

文献引用