Anti-IGF1R Antibody (Teprotumumab Biosimilar)

Name: Anti-IGF1R Antibody (Teprotumumab Biosimilar)
Brand: Puweituo Bio
SKU: IGF1R-AB001

Catalog numberIGF1R-AB001

HumanHEK293Molecular weight · 49.3 kDa

Product introduction

Anti-IGF1R Antibody (Teprotumumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target IGF1R, reactivity Human/Cynomolgus, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 49.3 kDa and 23.5 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Teprotumumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Teprotumumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human IGF1R, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Teprotumumab Biosimilar with the EC50 of 4.3ng/ml determined by ELISA. (QC Test)

Background

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

References

1.Riedemann J, Macaulay VM. IGF1R signalling and its inhibition. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S33-43. doi: 10.1677/erc.1.01280. PMID: 17259557.

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Anti-IGF1R Antibody (Teprotumumab Biosimilar)

Catalog numberIGF1R-AB001

HumanHEK293Molecular weight · 49.3 kDa

Anti-IGF1R Antibody (Teprotumumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-IGF1R Antibody (Teprotumumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References