Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein

Name: Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein
Brand: 普维拓生物
SKU: HPV16E6-HP001

货号HPV16E6-HP001

HumanHEK293分子名 · Human papillomavirus type 16理论分子量 · 50.50 kDa

产品简介

Recombinant Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and KLPQLCTEL peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &KLPQLCTEL).

产品详情

分子别名: Human papillomavirus type 16; HPV16; E6;
蛋白长度: Gly25-Thr305
表达系统: HEK293
理论分子量: The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
状态: 冻干粉
储存条件: -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
复溶建议: Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.

数据展示

Bis-Tris PAGE Data — Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer is greater than 95% as determined by SEC-HPLC.

背景介绍

Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer.

文献引用

1.Zhang L, Lai Y, Sun Y, Xu B, Qiang X, Zhou X, Wang T. HPV16 E6 regulates the proliferation, invasion, and apoptosis of cervical cancer cells by downregulating miR-504. Transl Cancer Res. 2020 Dec;9(12):7588-7595. doi: 10.21037/tcr-20-2913. PMID: 35117358; PMCID: PMC8799100.

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Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein

货号HPV16E6-HP001

HumanHEK293分子名 · Human papillomavirus type 16理论分子量 · 50.50 kDa

Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用

Human HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用