Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein

Name: Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein
Brand: 普维拓生物
SKU: HLAA1101-HP001

货号HLAA1101-HP001

HumanE. coli分子名 · RAS11B理论分子量 · 35.36 kDa

产品简介

Recombinant Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and AVVGASGVGK peptide (accession: AAV53343.1(HLA-A*11:01) & P61769(B2M) &AVVGASGVGK).

产品详情

分子别名: RAS11B; AVVGASGVGK; RASL11B
蛋白长度: Gly25-Thr305
表达系统: E. coli
理论分子量: The protein has a predicted MW of 35.36 kDa (HLA-A*11:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer is greater than 90% as determined by SEC-HPLC.

背景介绍

RAS (H-ras, K-ras, and N-ras), as the second largest mutated gene driver in various human cancers, has long been a vital research target for cancer. Its function is to transform the extracellular environment into a cascade of intracellular signal transduction. RAS mutant protein regulates tumor cell proliferation, apoptosis, metabolism and angiogenesis through downstream MAPK, PI3K and other signaling pathways.

文献引用

1.Chen S, Li F, Xu D, Hou K, Fang W, Li Y. The Function of RAS Mutation in Cancer and Advances in its Drug Research. Curr Pharm Des. 2019;25(10):1105-1114. doi: 10.2174/1381612825666190506122228. PMID: 31057104.

加载中…

Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein

货号HLAA1101-HP001

HumanE. coli分子名 · RAS11B理论分子量 · 35.36 kDa

Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用

Human HLA-A*11:01&B2M&RASL11B (AVVGASGVGK) Monomer Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

背景介绍

文献引用