Human GPRC5D Nanodisc Protein

Name: Human GPRC5D Nanodisc Protein
Brand: 普维拓生物
SKU: GPRC5D-HP002

货号GPRC5D-HP002

HumanHEK293分子名 · GPRC5D

产品简介

Human GPRC5D Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human GPRC5D Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val345 (accession: Q9NZD1-1).

产品详情

分子别名: GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
蛋白长度: Met1-Val345
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.

文献引用

1.Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.

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