Human GCGR/Glucagon receptor VLP Protein

Name: Human GCGR/Glucagon receptor VLP Protein
Brand: 普维拓生物
SKU: GCGR-HP001

货号GCGR-HP001

HumanHEK293分子名 · Glucagon receptor理论分子量 · 56 kDa

产品简介

Human GCGR/Glucagon receptor VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human GCGR/Glucagon receptor VLP is expressed from HEK293. It contains Met1-Phe477 (It may have cross reaction with anti-His antibody) (accession: P47871).

产品详情

分子别名: Glucagon receptor; GL-R; GCGR; Glucagon R
蛋白长度: Met1-Phe477
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 56 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.

文献引用

1.Kaur S, Sokrat B, Capozzi ME, El K, Bai Y, Jazic A, Han B, Krishna Kumar K, D'Alessio DA, Campbell JE, Bouvier M, Shenoy SK. The ubiquitination status of the glucagon receptor determines signal bias. J Biol Chem. 2023 May;299(5):104690. doi: 10.1016/j.jbc.2023.104690. Epub 2023 Apr 8. PMID: 37037304; PMCID: PMC10200972.

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Human GCGR/Glucagon receptor VLP Protein

货号GCGR-HP001

HumanHEK293分子名 · Glucagon receptor理论分子量 · 56 kDa