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Recombinant Human CXCL9 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the N-terminus. It contains amino acid residues Thr23-Thr125 (UniProt accession: Q07325).
Chemokine CXCL9 is a member of the CXC family and has an important role in the chemotaxis of immune cells. It is secreted by various cell types including immune cells (T lymphocytes, NK cells 3, dendritic cells 4, macrophages 5, eosinophils 6, etc.), and non-immune cells (hepatic stellate cells 7, preadipocytes, thyrocytes 8, endothelial cell, tumor cells, and fibroblasts 9, etc). CXCL9 has a versatile and controversial role in tumors, and accumulating evidence suggests that CXCL9 is closely associated with the prognosis of tumor patients.
