Biotinylated Human Claudin 18.2 Nanodisc Protein

Name: Biotinylated Human Claudin 18.2 Nanodisc Protein
Brand: 普维拓生物
SKU: CLDN182-HB002

货号CLDN182-HB002

HumanHEK293分子名 · CLDN18

产品简介

Biotinylated Human Claudin 18.2 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human Claudin 18.2 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val261 (accession: P56856-2).

产品详情

分子别名: CLDN18; CLDN18.2; Claudin-18.2; Claudin18.2; Claudin-18; DKFZp564B2062; SFTA5; SFTPJ
蛋白长度: Met1-Val261
表达系统: HEK293
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

Claudin18 (CLDN18) belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. Isoform 2 (Claudin 18.2) is abundant in gastric tumors.

文献引用

1.(1) Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer[J]. Journal of Hematology & Oncology, 2017, 10(1):105.

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