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Recombinant Biotinylated Human CD81 Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Tyr236 (UniProt accession: P60033).
CD81 (TAPA-1) is a member of the tetraspanin family, a large group of evolutionary conserved membrane proteins containing 4 transmembrane domains. The most distinctive feature of the tetraspanin proteins is the ability to form lateral associations with one another and to cluster dynamically with multiple cell surface receptors. Tetraspanins are capable of recruiting specific intracellular signaling enzymes, including protein kinase C, that is known to be involved in integrin phosphorylation.
