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Anti-CD38 Antibody (Daratumumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CD38, reactivity Human, isotype Human IgG1-Kappa, source-listed application ELISA.
CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether, this has triggered the development of several CD38 antibodies including daratumumab (fully human), isatuximab (chimeric), and MOR202 (fully human).
