Anti-CD38 Antibody (Daratumumab Biosimilar)

Name: Anti-CD38 Antibody (Daratumumab Biosimilar)
Brand: Puweituo Bio
SKU: CD38-AB001

Catalog numberCD38-AB001

HumanHEK293Molecular weight · 23.4 kDa

Product introduction

Anti-CD38 Antibody (Daratumumab Biosimilar) is a research-use biosimilar antibody expressed in HEK293. The source page specifies target CD38, reactivity Human, isotype Human IgG1-Kappa, source-listed application ELISA.

Product details

Expression system: HEK293
Molecular weight: 23.4 kDa and 49.3 kDa.
Purity: > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: PBS, 10% glycerol (pH 7.4)
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Daratumumab Biosimilar on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEC-HPLC Data — The purity of Daratumumab Biosimilar is greater than 95% as determined by SEC-HPLC.

ELISA Data — Immobilized Human CD38, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Daratumumab Biosimilar with the EC50 of 4.7ng/ml determined by ELISA. (QC Test)

Background

CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether, this has triggered the development of several CD38 antibodies including daratumumab (fully human), isatuximab (chimeric), and MOR202 (fully human).

References

1.PMID: 29118010.

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Anti-CD38 Antibody (Daratumumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References

Anti-CD38 Antibody (Daratumumab Biosimilar)

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

SEC-HPLC

SEC-HPLC Data

ELISA

ELISA Data

Background

References