Biotinylated Human CD20/MS4A1 VLP Protein

Name: Biotinylated Human CD20/MS4A1 VLP Protein
Brand: 普维拓生物
SKU: CD20-HB001

货号CD20-HB001

HumanHEK293分子名 · MS4A1理论分子量 · 34.3 kDa

产品简介

Biotinylated Human CD20/MS4A1 VLP Protein is a full-length multi-pass membrane protein presented in a VLP format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CD20/MS4A1 VLP is expressed from HEK293. It contains Met1-Pro297 (It may have cross reaction with anti-His antibody) (accession: P11836-1).

产品详情

分子别名: MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7
蛋白长度: Met1-Pro297
表达系统: HEK293
理论分子量: The target protein has a predicted MW of 34.3 kDa.
纯度: > 95% as determined by HPLC
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.

背景介绍

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R, CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.

文献引用

1.(1)Ma D, Mcdevitt M R, Barendswaard E, et al. Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies[J]. Leukemia, 2002, 16(1):60-66. (2)Jager U, Fridrik M, Zeitlinger M, et al. Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response[J]. Haematologica, 2012, 97(9):1431-1438.

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Biotinylated Human CD20/MS4A1 VLP Protein

货号CD20-HB001

HumanHEK293分子名 · MS4A1理论分子量 · 34.3 kDa