Human IL-7 R alpha/CD127 Protein

Name: Human IL-7 R alpha/CD127 Protein
Brand: 普维拓生物
SKU: CD127-HF002

货号CD127-HF002

HumanHEK293分子名 · IL-7R alpha理论分子量 · 38.84 kDa

产品简介

Recombinant Human IL-7 R alpha/CD127 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Ala131-Asp239 (UniProt accession: P16871-1).

产品详情

分子别名: IL-7R alpha; IL7Ra; CD127; CDW127; IL7Rα; IL7R alpha
蛋白长度: Ala131-Asp239
表达系统: HEK293
理论分子量: The protein has a predicted MW of 38.84 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Bis-Tris PAGE result.
纯度: > 95% as determined by Bis-Tris PAGE
内毒素: Less than 1 EU per μg by the LAL method.
缓冲液 / 制剂: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
储存条件: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

数据展示

Bis-Tris PAGE Data — Human IL-7 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

背景介绍

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.

文献引用

1.Oliveira ML, Akkapeddi P, Ribeiro D, Melão A, Barata JT. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update. Adv Biol Regul. 2019 Jan;71:88-96. doi: 10.1016/j.jbior.2018.09.012. Epub 2018 Sep 19. PMID: 30249539; PMCID: PMC6386770.

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Human IL-7 R alpha/CD127 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用

Human IL-7 R alpha/CD127 Protein

产品简介

产品详情

数据展示

Bis-Tris PAGE

Bis-Tris PAGE Data

背景介绍

文献引用