Human IL-7 R alpha/CD127 Protein

Name: Human IL-7 R alpha/CD127 Protein
Brand: Puweituo Bio
SKU: CD127-HF002

Catalog numberCD127-HF002

HumanHEK293Molecule · IL-7R alphaMolecular weight · 38.84 kDa

Product introduction

Recombinant Human IL-7 R alpha/CD127 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Ala131-Asp239 (UniProt accession: P16871-1).

Product details

Molecular aliases: IL-7R alpha; IL7Ra; CD127; CDW127; IL7Rα; IL7R alpha
Protein length: Ala131-Asp239
Expression system: HEK293
Molecular weight: The protein has a predicted MW of 38.84 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Bis-Tris PAGE result.
Purity: > 95% as determined by Bis-Tris PAGE
Endotoxin: Less than 1 EU per μg by the LAL method.
Formulation: Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Storage: Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Data display

Bis-Tris PAGE Data — Human IL-7 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Background

Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth.

References

1.Oliveira ML, Akkapeddi P, Ribeiro D, Melão A, Barata JT. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update. Adv Biol Regul. 2019 Jan;71:88-96. doi: 10.1016/j.jbior.2018.09.012. Epub 2018 Sep 19. PMID: 30249539; PMCID: PMC6386770.

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Human IL-7 R alpha/CD127 Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

Background

References

Human IL-7 R alpha/CD127 Protein

Product introduction

Product details

Data display

Bis-Tris PAGE

Bis-Tris PAGE Data

Background

References